EXECUTIVE HEALTH CHECKUP

This checkup Programm is recommended for people with a middle to high riskfactor. This program is the same as the standard extensive health checkup plus 2 additional tests based on the individual needs if the 'patient'.

Executive health checkup

Standard extensive health checkup plus up to two of the following supplementary check-up services.

• Cardiovascular

Multi-slice computed tomography (MSCT) of the heart (calcium-scoring (CAC) or non-invasive coronary angiogram (CCTA), depending on the indication). Integration of these findings into the functional cardiac examination and resulting consultation *) Such supplementary services will be selected on the basis of an algorithm calculated from the standard diagnostic methods, i.e. the individual risk situation, in line with the guidelines of professional associations.

• Musculoskeletal system

Clinical orthopaedic history, functional examination considering the MRI findings from the spine and joints as part of the total-body MRI, and resulting advice.

• Female health (gynaecology)

Gynaecological history and physical examination Hormone status: FSH ECLIA, estradiol E2 Ultrasound scan

- Intravaginal sonogram

- 3D breast sonogram Mammography (over the age of 50) Resulting advice

• Male health (urology/andrology)

Urological history and physical examination Hormone status: SHBG, prolactin, LH, FSH ECLIA (testosterone is determined during the standard check-up) Urological ultrasound scan

- Sonogram of the kidneys and bladder - Transrectal sonogram of the prostate and seminal glands - Sonogram of the external genitalia

Investigation, if necessary, of erectile dysfunction (in collaboration with a cardiologist) Resulting advice

• 'Virtual' intestinal check-up

Over the age of 50 Gastroenterological history and physical examination Virtual coloscopy (preferably with low-dose CT, possibly MRI): Non-invasive instead of conventional endoscopy as screening for colon cancer *) Resulting advice

• 'Conventional' intestinal check-up

Over the age of 50 or if there are symptoms/depending on indication Gastroenterological history and physical examination Optical coloscopy: conventional endoscopy as screening for colon cancer Resulting advice

• Gastroduodenoscopy (gastroscopy/duodenoscopy)

In the event of abnormal sensations or discomfort Gastroenterological history and physical examination Optical gastroscopy: conventional endoscopy Resulting advice

• ENT examination

Specific ENT history and physical examination Ear microscopy Measurement of eardrum vibrations Nasal endoscopy

Examination of the larynx Audiometry (hearing test), separately for each ear Resulting advice

• Dental check

Professional dental cleaning to distinguish harmless discolorations from caries Dental and caries screening, vitality check, assessment of any existing restorations Examination of mucous membranes Paradontal screening index, PSI Function check, assessment of masticatory muscles and mandibular joint, compression and grinding habits X-ray Oral hygiene check Resulting consultation

• Rheumatology screening

In the event of abnormal sensations or discomfort Specific rheumatological history and physical examination Documentation of previous infections, symptoms associated with collagenosis (involving the connective tissue), symptoms accompanying soft-tissue rheumatism, specific documentation of the joint and spine status

Specific rheumatology tests: - Citrulline antibodies - Antinuclear antibodies, if positive/above a titre of 1:160 - Profile of extractable antibodies/ENA plus determination of dsDNA antibodies - Complement factors C3, C4 - HLA B27 typification - Facultative: TRAB/anti-TPO

Resulting advice.

• Pulmonary screening (in smokers)

Pneumological history and physical examination Low-dose multi-slice computed tomography (MSCT) of the lungs *) Sputum cytology Resulting advice

Such supplementary services will be selected on the basis of the individual risk situation and individual preferences, in line with the guidelines of professional associations. To schedule the check-up, a preliminary telephone or on-site consultation will be held with EPC's preventive medicine specialist.

• Nicotine withdrawal

Smoking history including Fagerström test to ascertain potential dependence (see standard check-up). Success-oriented, individual coaching/follow-up with qualified psychologist (2 to 4 appointments plus follow-up, if necessary, on the telephone), including relapse prophylaxis by anticipating critical situations and developing behavioural alternatives. (Entirely individual program with one-on-one coaching) Accompanying pharmacotherapy (preferably with varenicline, Champix®) [Details of program provided on request]